DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VGLTPGQE
Uniprot ID:
Q9P266
Source protein:
Junctional protein associated with coronary artery disease
Source gene:
JCAD
Class:
DEG_SCF_FBW7_2
Location:
1051:1058
E3 ligase:
FBXW7
DEGRON score:
0.9944
ASA_SCORE:
83.9125
COIL:
0.9154
CONS_SCORE:
0.4941
DSS_SCORE:
0.6389
HELIX:
0.0355
FCONS_SCORE:
1.1105
RIG_SCORE:
0.6378
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with JCAD mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VGLTPGQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P266
Junctional protein associated with coronary artery disease
DEG_SCF_FBW7_2
1051:1058
VGLTPGQE
FBXW7
0.9944
More...