DegronMD

Uniprot ID: Q8WUU5

Source protein: GATA zinc finger domain-containing protein 1

Source gene: GATAD1

Class: DEG_SCF_FBW7_1

Location: 253:260

E3 ligase: FBXW7

DEGRON score: 0.9873

ASA_SCORE: 58.8

COIL: 0.8589

CONS_SCORE: 0.4397

DSS_SCORE: 0.3424

HELIX: 0.021

FCONS_SCORE: 0.9194

RIG_SCORE: 0.7778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V265F	DO228948	LICA	ICGC	VGPTPAIT	DEG_SCF_FBW7_1	0.1944
p.G254W	DO229018	LICA	ICGC	VGPTPAIT	DEG_SCF_FBW7_1	0.6714
p.V253F	DO229019	LICA	ICGC	VGPTPAIT	DEG_SCF_FBW7_1	0.7068
p.A258S	DO229008	LICA	ICGC	VGPTPAIT	DEG_SCF_FBW7_1	0.6477
p.A266V	DO220889	MELA	ICGC	VGPTPAIT	DEG_SCF_FBW7_1	0.1667
p.P257L	SIDM01121	Small Cell Lung Carcinoma	GDSC	VGPTPAIT	DEG_SCF_FBW7_1	0.7582
p.P257L	ACH-000358	Lung Cancer	CCLE	VGPTPAIT	DEG_SCF_FBW7_1	0.7582
p.P257L	NCI-H69	lung	COSMIC	VGPTPAIT	DEG_SCF_FBW7_1	0.7582
p.E245Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VGPTPAIT	DEG_SCF_FBW7_1	0.1111
p.E245Q	ACH-000916	Lung Cancer	CCLE	VGPTPAIT	DEG_SCF_FBW7_1	0.1111
p.E245Q	NCI-H1573	lung	COSMIC	VGPTPAIT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUU5	GATA zinc finger domain-containing protein 1	DEG_SCF_FBW7_1	253:260	VGPTPAIT	FBXW7	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons