DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_SCF_FBW7_1

Location: 866:872

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 77.6

COIL: 0.937

CONS_SCORE: 0.3717

DSS_SCORE: 0.7865

HELIX: 0.0333

FCONS_SCORE: 1.0292

RIG_SCORE: 0.6409

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L862F	TCGA-AP-A0LJ	UCEC	TCGA	VGTPPES	DEG_SCF_FBW7_1	0.2222
p.L862F	DO42145	UCEC	ICGC	VGTPPES	DEG_SCF_FBW7_1	0.2222
p.S878F	TCGA-EK-A2RJ	CESC	TCGA	VGTPPES	DEG_SCF_FBW7_1	0.1667
p.S878F	DO49950	CESC	ICGC	VGTPPES	DEG_SCF_FBW7_1	0.1667
p.Q856E	DO222675	ESCA	ICGC	VGTPPES	DEG_SCF_FBW7_1	0.0556
p.R876W	SIDM00993	Plasma Cell Myeloma	GDSC	VGTPPES	DEG_SCF_FBW7_1	0.2222
p.R876W	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPPES	DEG_SCF_FBW7_1	0.2222
p.R880W	ACH-000838	Myeloma	CCLE	VGTPPES	DEG_SCF_FBW7_1	0.1111
p.R880W	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPPES	DEG_SCF_FBW7_1	0.1111
p.D863E	ACH-001977	Primary	CCLE	VGTPPES	DEG_SCF_FBW7_1	0.25
p.R864W	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPPES	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	DEG_SCF_FBW7_1	866:872	VGTPPES	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons