DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VKTPALE
Uniprot ID:
P0CK96
Source protein:
Solute carrier family 35 member E2B
Source gene:
SLC35E2B
Class:
DEG_SCF_FBW7_2
Location:
5:11
E3 ligase:
FBXW7
DEGRON score:
0.9813
ASA_SCORE:
88.3714
COIL:
0.71
CONS_SCORE:
0.2919
DSS_SCORE:
0.7029
HELIX:
0.2906
FCONS_SCORE:
0.9893
RIG_SCORE:
0.7107
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G16V
ACH-000292
Lung Cancer
CCLE
VKTPALE
DEG_SCF_FBW7_2
0.1944
Drug responses associated with SLC35E2B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKTPALE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0CK97
Solute carrier family 35 member E2A
DEG_SCF_FBW7_2
5:11
VKTPALE
FBXW7
0.99
More...
P0CK96
Solute carrier family 35 member E2B
DEG_SCF_FBW7_2
5:11
VKTPALE
FBXW7
0.9813
More...