DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VKTPALE
Uniprot ID:
P0CK97
Source protein:
Solute carrier family 35 member E2A
Source gene:
SLC35E2A
Class:
DEG_SCF_FBW7_2
Location:
5:11
E3 ligase:
FBXW7
DEGRON score:
0.99
ASA_SCORE:
89.5286
COIL:
0.7167
CONS_SCORE:
0.2426
DSS_SCORE:
0.7029
HELIX:
0.27
FCONS_SCORE:
1.0545
RIG_SCORE:
0.7107
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SLC35E2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKTPALE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0CK97
Solute carrier family 35 member E2A
DEG_SCF_FBW7_2
5:11
VKTPALE
FBXW7
0.99
More...
P0CK96
Solute carrier family 35 member E2B
DEG_SCF_FBW7_2
5:11
VKTPALE
FBXW7
0.9813
More...