DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VLLYHE
Uniprot ID:
Q2TAK8
Source protein:
PWWP domain-containing DNA repair factor 3A
Source gene:
PWWP3A
Class:
LIG_APCC_ABBA_1
Location:
400:405
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8516
ASA_SCORE:
88.7333
COIL:
0.8082
CONS_SCORE:
0.6193
DSS_SCORE:
0.3816
HELIX:
0.1282
FCONS_SCORE:
0.8483
RIG_SCORE:
0.7946
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PWWP3A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VLLYHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2TAK8
PWWP domain-containing DNA repair factor 3A
LIG_APCC_ABBA_1
400:405
VLLYHE
APC,CDC20,FZR1
0.8516
More...