DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VLPYGD
Uniprot ID:
Q7Z7J9
Source protein:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Source gene:
CAMK2N1
Class:
LIG_APCC_ABBA_1
Location:
4:9
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9996
ASA_SCORE:
69.5
COIL:
0.8367
CONS_SCORE:
0.9501
DSS_SCORE:
0.65
HELIX:
0.0458
FCONS_SCORE:
1.0737
RIG_SCORE:
0.7464
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P6H
DO228941
LICA
ICGC
VLPYGD
LIG_APCC_ABBA_1
0.7694
p.G19S
DO229048
LICA
ICGC
VLPYGD
LIG_APCC_ABBA_1
0.0556
Drug responses associated with CAMK2N1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VLPYGD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z7J9
Calcium/calmodulin-dependent protein kinase II inhibitor 1
LIG_APCC_ABBA_1
4:9
VLPYGD
APC,CDC20,FZR1
0.9996
More...