CAMK2N1
UniProt ID: Q7Z7J9
Entrez ID: 55450
Protein name: Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CaMKII inhibitory protein alpha) (CaMKIIN-alpha)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to reg...
FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity). {ECO:0000250|UniProtKB:Q6QWF9, ECO:0000250|UniProtKB:Q9JI15}.
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GO - Biological processes (BP):
long-term memory [GO:0007616]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of inflammatory response [GO:0050729]...
long-term memory [GO:0007616]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of inflammatory response [GO:0050729]
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GO - Molecular function (MF):
calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901]...
calcium-dependent protein kinase inhibitor activity [GO:0008427]; protein kinase binding [GO:0019901]
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GO - Cellular component (CC):
neuron projection [GO:0043005]; postsynaptic density [GO:0014069]; synapse [GO:0045202]...
neuron projection [GO:0043005]; postsynaptic density [GO:0014069]; synapse [GO:0045202]
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CAMK2N1
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Kaplan plot for CAMK2N1 in
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*NOTE: the Kaplan plots were collected from OncoLnc