DegronMD

Uniprot ID: Q7Z7J9

Source protein: Calcium/calmodulin-dependent protein kinase II inhibitor 1

Source gene: CAMK2N1

Class: LIG_APCC_ABBA_1

Location: 12:17

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9193

ASA_SCORE: 62.1

COIL: 0.8132

CONS_SCORE: 0.858

DSS_SCORE: 0.4378

HELIX: 0.0455

FCONS_SCORE: 0.962

RIG_SCORE: 0.6841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P14L	TCGA-EE-A2GH	SKCM	TCGA	LSPYGD	LIG_APCC_ABBA_1	0.6471
p.P14L	DO37643	SKCM	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.6471
p.P14S	TCGA-EE-A2GH	SKCM	TCGA	LSPYGD	LIG_APCC_ABBA_1	0.6752
p.P14S	DO37643	SKCM	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.6752
p.G16S	TCGA-FR-A726	SKCM	TCGA	LSPYGD	LIG_APCC_ABBA_1	0.5882
p.G16S	DO48665	SKCM	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.5882
p.Q23R	DO227987	COCA	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.1667
p.I24M	DO15414	HNSC	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.G19S	DO229048	LICA	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY10	Thymic stromal cotransporter homolog	LIG_APCC_ABBA_1	466:471	LSPYGD	APC,CDC20,FZR1	0.5078	More...
Q7Z7J9	Calcium/calmodulin-dependent protein kinase II inhibitor 1	LIG_APCC_ABBA_1	12:17	LSPYGD	APC,CDC20,FZR1	0.9193	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons