DegronMD

Uniprot ID: Q9BY10

Source protein: Thymic stromal cotransporter homolog

Source gene: SLC46A2

Class: LIG_APCC_ABBA_1

Location: 466:471

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5078

ASA_SCORE: 99.9333

COIL: 0.9128

CONS_SCORE: 0.3364

DSS_SCORE: 0.156

HELIX: 0.0642

FCONS_SCORE: 0.7132

RIG_SCORE: 0.7998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E474D	TCGA-EO-A22X	UCEC	TCGA	LSPYGD	LIG_APCC_ABBA_1	0.25
p.E474D	DO43907	UCEC	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.25
p.D471E	DO228948	LICA	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.5647
p.P468Q	DO229015	LICA	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.7035
p.S457N	DO232224	PBCA	ICGC	LSPYGD	LIG_APCC_ABBA_1	0.0833
p.V459M	SIDM00061	Ovarian Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM01149	Small Cell Lung Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM00230	Small Cell Lung Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM00102	Mesothelioma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM00796	Head and Neck Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM00516	Melanoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM01051	Ovarian Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM00622	Glioblastoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM01012	Other Blood Cancers	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM01879	Non-Cancerous	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM01228	Melanoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389
p.V459M	SIDM01598	Non-Small Cell Lung Carcinoma	GDSC	LSPYGD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY10	Thymic stromal cotransporter homolog	LIG_APCC_ABBA_1	466:471	LSPYGD	APC,CDC20,FZR1	0.5078	More...
Q7Z7J9	Calcium/calmodulin-dependent protein kinase II inhibitor 1	LIG_APCC_ABBA_1	12:17	LSPYGD	APC,CDC20,FZR1	0.9193	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons