DegronMD

Uniprot ID: B2RXF5

Source protein: Zinc finger and BTB domain-containing protein 42

Source gene: ZBTB42

Class: DEG_SCF_FBW7_1

Location: 206:213

E3 ligase: FBXW7

DEGRON score: 0.9833

ASA_SCORE: 77.5875

COIL: 0.7458

CONS_SCORE: 0.8265

DSS_SCORE: 0.5731

HELIX: 0.1136

FCONS_SCORE: 0.9859

RIG_SCORE: 0.7291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H202L	TCGA-2H-A9GL	ESCA	TCGA	VLQTPLCS	DEG_SCF_FBW7_1	0.2222
p.H202Q	TCGA-DX-A48V	SARC	TCGA	VLQTPLCS	DEG_SCF_FBW7_1	0.2222
p.H202Q	DO219991	SARC	ICGC	VLQTPLCS	DEG_SCF_FBW7_1	0.2222
p.V206F	DO229041	LICA	ICGC	VLQTPLCS	DEG_SCF_FBW7_1	0.7068
p.Q208H	DO26427	LUSC	ICGC	VLQTPLCS	DEG_SCF_FBW7_1	0.647
p.P203T	DO229224	THCA	ICGC	VLQTPLCS	DEG_SCF_FBW7_1	0.25
p.L211I	ACH-000967	Colon/Colorectal Cancer	CCLE	VLQTPLCS	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
B2RXF5	Zinc finger and BTB domain-containing protein 42	DEG_SCF_FBW7_1	206:213	VLQTPLCS	FBXW7	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons