DegronMD

Uniprot ID: Q8TBZ2

Source protein: MYCBP-associated protein

Source gene: MYCBPAP

Class: DEG_SCF_FBW7_1

Location: 574:580

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 81.4571

COIL: 0.9334

CONS_SCORE: 0.597

DSS_SCORE: 0.3454

HELIX: 0.026

FCONS_SCORE: 1.0907

RIG_SCORE: 0.7477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L570I	TCGA-19-5956	GBM	TCGA	VLTPERT	DEG_SCF_FBW7_1	0.2222
p.L570I	DO13863	GBM	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.2222
p.R584S	TCGA-A5-A0G2	UCEC	TCGA	VLTPERT	DEG_SCF_FBW7_1	0.2222
p.S589I	TCGA-AP-A1E0	UCEC	TCGA	VLTPERT	DEG_SCF_FBW7_1	0.0833
p.E588K	TCGA-DK-A3X1	BLCA	TCGA	VLTPERT	DEG_SCF_FBW7_1	0.1111
p.E588K	DO447	BLCA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.1111
p.V579I	TCGA-FV-A496	LIHC	TCGA	VLTPERT	DEG_SCF_FBW7_1	0.7076
p.V579I	DO44966	LIHC	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.7076
p.S574F	TCGA-HC-7233	PRAD	TCGA	VLTPERT	DEG_SCF_FBW7_1	0.7982
p.L588F	DO225332	BRCA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.1111
p.R579H	DO225346	BRCA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.7133
p.R579H	DO220867	MELA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.7133
p.R564C	DO233728	GACA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.0556
p.E590K	DO233869	GACA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.0556
p.P577L	DO16023	HNSC	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.7582
p.A586S	DO229022	LICA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.1667
p.R579C	DO35186	PACA	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.719
p.P583H	DO42600	UCEC	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.25
p.A586V	DO41271	UCEC	ICGC	VLTPERT	DEG_SCF_FBW7_1	0.1667
p.I565V	SIDM00530	Esophageal Carcinoma	GDSC	VLTPERT	DEG_SCF_FBW7_1	0.0833
p.I565V	ACH-001544	Esophageal Cancer	CCLE	VLTPERT	DEG_SCF_FBW7_1	0.0833
p.I565V	KYAE-1	oesophagus	COSMIC	VLTPERT	DEG_SCF_FBW7_1	0.0833
p.S589N	SIDM00683	Prostate Carcinoma	GDSC	VLTPERT	DEG_SCF_FBW7_1	0.0833
p.S589N	LNCaP-Clone-FGC	prostate	COSMIC	VLTPERT	DEG_SCF_FBW7_1	0.0833
p.L571V	OVCAR-5	ovary	COSMIC	VLTPERT	DEG_SCF_FBW7_1	0.25
p.L571V	RD	soft_tissue	COSMIC	VLTPERT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBZ2	MYCBP-associated protein	DEG_SCF_FBW7_1	574:580	VLTPERT	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons