DegronMD

Uniprot ID: Q12772

Source protein: Sterol regulatory element-binding protein 2

Source gene: SREBF2

Class: DEG_SCF_FBW7_1

Location: 150:157

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 102.4125

COIL: 0.9426

CONS_SCORE: 0.3343

DSS_SCORE: 0.5198

HELIX: 0.0144

FCONS_SCORE: 1.0115

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q144E	TCGA-XF-A9T8	BLCA	TCGA	VMITPTFS	DEG_SCF_FBW7_1	0.1667
p.Q144E	DO51927	BLCA	ICGC	VMITPTFS	DEG_SCF_FBW7_1	0.1667
p.Q144E	SIDM00332	Breast Carcinoma	GDSC	VMITPTFS	DEG_SCF_FBW7_1	0.1667
p.Q144E	ACH-001819	Breast Cancer	CCLE	VMITPTFS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12772	Sterol regulatory element-binding protein 2	DEG_SCF_FBW7_1	150:157	VMITPTFS	FBXW7	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons