DegronMD - Q12772(SREBF2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R625C	TCGA-06-0126	GBM	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0833
p.R625C	DO11519	GBM	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0833
p.P118L	TCGA-A5-A0G1	UCEC	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.25
p.P118L	DO42472	UCEC	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.25
p.R646W	TCGA-A6-5661	COAD	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.2222
p.R646W	DO8634	COAD	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.2222
p.K639N	TCGA-AJ-A2QM	UCEC	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.5806
p.K639N	TCGA-AX-A05Z	UCEC	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.5806
p.K639N	DO40884	UCEC	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.5806
p.K639N	DO43690	UCEC	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.5806
p.V634M	TCGA-CG-4436	STAD	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.6097
p.V634M	DO38320	STAD	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.6097
p.P122S	TCGA-D3-A3MR	SKCM	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation altering degron motif	0.5641
p.P122S	TCGA-EE-A2MJ	SKCM	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation altering degron motif	0.5641
p.P122S	DO220851	MELA	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation altering degron motif	0.5641
p.P122S	DO47256	SKCM	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation altering degron motif	0.5641
p.P122S	DO38099	SKCM	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation altering degron motif	0.5641
p.P135L	TCGA-FW-A3R5	SKCM	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.1389
p.P135L	DO37406	SKCM	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.1389
p.Q144E	TCGA-XF-A9T8	BLCA	TCGA	VMITPTFS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1667
p.Q144E	DO51927	BLCA	ICGC	VMITPTFS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1667
p.Q144E	SIDM00332	Breast Carcinoma	GDSC	VMITPTFS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1667
p.Q144E	ACH-001819	Breast Cancer	CCLE	VMITPTFS	DEG_SCF_FBW7_1	150:157	Mutation rewiring degron network	0.1667
p.R134H	TCGA-XK-AAIW	PRAD	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.1667
p.R134H	DO51407	PRAD	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.1667
p.L131I	DO233284	GACA	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.25
p.Q136H	DO228978	LICA	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation rewiring degron network	0.1111
p.T124I	SIDM02035	Colorectal Carcinoma	GDSC	VPTTPRAT	DEG_SCF_FBW7_1	121:128	Mutation altering degron motif	0.8189
p.L638F	SIDM00789	Colorectal Carcinoma	GDSC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.6981
p.L638F	SIDM00829	Acute Myeloid Leukemia	GDSC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.6981
p.L638F	HL-60	haematopoietic and lymphoid tissue	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.6981
p.E652D	SIDM00596	Endometrial Carcinoma	GDSC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0556
p.E652D	ACH-000941	Endometrial/Uterine Cancer	CCLE	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0556
p.E652D	ACH-000954	Endometrial/Uterine Cancer	CCLE	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0556
p.E652D	ACH-001517	Endometrial/Uterine Cancer	CCLE	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0556
p.E652D	HEC-1	endometrium	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.0556
p.A647P	IPC-298	skin	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.1944
p.A641V	HL-60	haematopoietic and lymphoid tissue	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation altering degron motif	0.6936
p.G650A	IPC-298	skin	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	634:642	Mutation rewiring degron network	0.1111

Kaplan plot for SREBF2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SREBF2

UniProt ID: Q12772

Entrez ID: 6721

Protein name: Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2 (Transcription factor SREBF2)]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SREBF2 in