DegronMD

Uniprot ID: Q12772

Source protein: Sterol regulatory element-binding protein 2

Source gene: SREBF2

Class: DEG_APCC_DBOX_1

Location: 634:642

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7405

ASA_SCORE: 46.3778

COIL: 0.198

CONS_SCORE: 0.5112

DSS_SCORE: 0.0345

HELIX: 0.7676

FCONS_SCORE: 1.2515

RIG_SCORE: 0.9808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R625C	TCGA-06-0126	GBM	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	0.0833
p.R625C	DO11519	GBM	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	0.0833
p.R646W	TCGA-A6-5661	COAD	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	0.2222
p.R646W	DO8634	COAD	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	0.2222
p.K639N	TCGA-AJ-A2QM	UCEC	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	0.5806
p.K639N	TCGA-AX-A05Z	UCEC	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	0.5806
p.K639N	DO40884	UCEC	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	0.5806
p.K639N	DO43690	UCEC	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	0.5806
p.V634M	TCGA-CG-4436	STAD	TCGA	VRWLLKKVF	DEG_APCC_DBOX_1	0.6097
p.V634M	DO38320	STAD	ICGC	VRWLLKKVF	DEG_APCC_DBOX_1	0.6097
p.L638F	SIDM00789	Colorectal Carcinoma	GDSC	VRWLLKKVF	DEG_APCC_DBOX_1	0.6981
p.L638F	SIDM00829	Acute Myeloid Leukemia	GDSC	VRWLLKKVF	DEG_APCC_DBOX_1	0.6981
p.L638F	HL-60	haematopoietic_and_lymphoid_tissue	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	0.6981
p.E652D	SIDM00596	Endometrial Carcinoma	GDSC	VRWLLKKVF	DEG_APCC_DBOX_1	0.0556
p.E652D	ACH-000941	Endometrial/Uterine Cancer	CCLE	VRWLLKKVF	DEG_APCC_DBOX_1	0.0556
p.E652D	ACH-000954	Endometrial/Uterine Cancer	CCLE	VRWLLKKVF	DEG_APCC_DBOX_1	0.0556
p.E652D	ACH-001517	Endometrial/Uterine Cancer	CCLE	VRWLLKKVF	DEG_APCC_DBOX_1	0.0556
p.E652D	HEC-1	endometrium	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	0.0556
p.A647P	IPC-298	skin	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	0.1944
p.A641V	HL-60	haematopoietic_and_lymphoid_tissue	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	0.6936
p.G650A	IPC-298	skin	COSMIC	VRWLLKKVF	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12772	Sterol regulatory element-binding protein 2	DEG_APCC_DBOX_1	634:642	VRWLLKKVF	APC,CDC20,FZR1	0.7405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons