DegronMD

Uniprot ID: Q12772

Source protein: Sterol regulatory element-binding protein 2

Source gene: SREBF2

Class: DEG_SCF_FBW7_1

Location: 121:128

E3 ligase: FBXW7

DEGRON score: 0.9843

ASA_SCORE: 93.275

COIL: 0.9639

CONS_SCORE: 0.332

DSS_SCORE: 0.6923

HELIX: 0.0111

FCONS_SCORE: 0.9699

RIG_SCORE: 0.6281

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P118L	TCGA-A5-A0G1	UCEC	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	0.25
p.P118L	DO42472	UCEC	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.25
p.P122S	TCGA-D3-A3MR	SKCM	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	0.5641
p.P122S	TCGA-EE-A2MJ	SKCM	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	0.5641
p.P122S	DO220851	MELA	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.5641
p.P122S	DO47256	SKCM	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.5641
p.P122S	DO38099	SKCM	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.5641
p.P135L	TCGA-FW-A3R5	SKCM	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	0.1389
p.P135L	DO37406	SKCM	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.1389
p.R134H	TCGA-XK-AAIW	PRAD	TCGA	VPTTPRAT	DEG_SCF_FBW7_1	0.1667
p.R134H	DO51407	PRAD	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.1667
p.L131I	DO233284	GACA	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.25
p.Q136H	DO228978	LICA	ICGC	VPTTPRAT	DEG_SCF_FBW7_1	0.1111
p.T124I	SIDM02035	Colorectal Carcinoma	GDSC	VPTTPRAT	DEG_SCF_FBW7_1	0.8189

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12772	Sterol regulatory element-binding protein 2	DEG_SCF_FBW7_1	121:128	VPTTPRAT	FBXW7	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons