DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 4488:4492

E3 ligase: SPOP

DEGRON score: 0.6964

ASA_SCORE: 73.48

COIL: 0.527

CONS_SCORE: 0.6943

DSS_SCORE: 0.7666

HELIX: 0.0312

FCONS_SCORE: 0.9702

RIG_SCORE: 0.7684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4490M	TCGA-28-5216	GBM	TCGA	VMTTS	DEG_SPOP_SBC_1	0.7423
p.T4490M	TCGA-AC-A62Y	BRCA	TCGA	VMTTS	DEG_SPOP_SBC_1	0.7423
p.T4490M	TCGA-CG-5719	STAD	TCGA	VMTTS	DEG_SPOP_SBC_1	0.7423
p.T4490M	DO49021	BRCA	ICGC	VMTTS	DEG_SPOP_SBC_1	0.7423
p.T4490M	DO11513	GBM	ICGC	VMTTS	DEG_SPOP_SBC_1	0.7423
p.T4490M	DO38827	STAD	ICGC	VMTTS	DEG_SPOP_SBC_1	0.7423
p.Q4487H	TCGA-2Y-A9H3	LIHC	TCGA	VMTTS	DEG_SPOP_SBC_1	0.3056
p.Q4487H	DO219525	LIHC	ICGC	VMTTS	DEG_SPOP_SBC_1	0.3056
p.R4482Q	TCGA-AA-A010	COAD	TCGA	VMTTS	DEG_SPOP_SBC_1	0.1667
p.R4482Q	SIDM01126	Small Cell Lung Carcinoma	GDSC	VMTTS	DEG_SPOP_SBC_1	0.1667
p.R4482Q	SIDM00846	Cervical Carcinoma	GDSC	VMTTS	DEG_SPOP_SBC_1	0.1667
p.R4482Q	SIDM00633	Breast Carcinoma	GDSC	VMTTS	DEG_SPOP_SBC_1	0.1667
p.R4482Q	SIDM01588	Endometrial Carcinoma	GDSC	VMTTS	DEG_SPOP_SBC_1	0.1667
p.I4483M	TCGA-B5-A0JY	UCEC	TCGA	VMTTS	DEG_SPOP_SBC_1	0.1944
p.I4483M	DO43041	UCEC	ICGC	VMTTS	DEG_SPOP_SBC_1	0.1944
p.F4493L	TCGA-BS-A0UV	UCEC	TCGA	VMTTS	DEG_SPOP_SBC_1	0.3056
p.F4493L	DO42793	UCEC	ICGC	VMTTS	DEG_SPOP_SBC_1	0.3056
p.P4486H	TCGA-E6-A1LX	UCEC	TCGA	VMTTS	DEG_SPOP_SBC_1	0.2778
p.P4486H	DO41020	UCEC	ICGC	VMTTS	DEG_SPOP_SBC_1	0.2778
p.E4478K	TCGA-EE-A2M6	SKCM	TCGA	VMTTS	DEG_SPOP_SBC_1	0.0556
p.E4478K	DO222514	MELA	ICGC	VMTTS	DEG_SPOP_SBC_1	0.0556
p.E4478K	DO37976	SKCM	ICGC	VMTTS	DEG_SPOP_SBC_1	0.0556
p.R4485M	TCGA-VQ-A8P2	STAD	TCGA	VMTTS	DEG_SPOP_SBC_1	0.25
p.R4485M	DO51761	STAD	ICGC	VMTTS	DEG_SPOP_SBC_1	0.25
p.T4490A	SIDM01617	Endometrial Carcinoma	GDSC	VMTTS	DEG_SPOP_SBC_1	0.7139
p.T4490A	ACH-000994	Endometrial/Uterine Cancer	CCLE	VMTTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4488:4492	VMTTS	SPOP	0.6964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons