DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VMVHPD
Uniprot ID:
Q6Y2X3
Source protein:
DnaJ homolog subfamily C member 14
Source gene:
DNAJC14
Class:
LIG_APCC_ABBA_1
Location:
468:473
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5215
ASA_SCORE:
66.1333
COIL:
0.4642
CONS_SCORE:
0.8391
DSS_SCORE:
0.4076
HELIX:
0.5333
FCONS_SCORE:
1.2466
RIG_SCORE:
0.7615
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E482Q
TCGA-44-2662
LUAD
TCGA
VMVHPD
LIG_APCC_ABBA_1
0.0833
p.E482Q
DO26290
LUAD
ICGC
VMVHPD
LIG_APCC_ABBA_1
0.0833
p.N475S
TCGA-55-8204
LUAD
TCGA
VMVHPD
LIG_APCC_ABBA_1
0.2778
p.N475S
DO45322
LUAD
ICGC
VMVHPD
LIG_APCC_ABBA_1
0.2778
p.V470A
SIDM01154
T-Lymphoblastic Leukemia
GDSC
VMVHPD
LIG_APCC_ABBA_1
0.6936
p.V470A
SUP-T1
haematopoietic_and_lymphoid_tissue
COSMIC
VMVHPD
LIG_APCC_ABBA_1
0.6936
p.E481D
SIDM00282
Colorectal Carcinoma
GDSC
VMVHPD
LIG_APCC_ABBA_1
0.1111
p.E481D
CW-2
large_intestine
COSMIC
VMVHPD
LIG_APCC_ABBA_1
0.1111
p.A462V
SIDM00901
Endometrial Carcinoma
GDSC
VMVHPD
LIG_APCC_ABBA_1
0.1667
p.A462V
AN3-CA
endometrium
COSMIC
VMVHPD
LIG_APCC_ABBA_1
0.1667
Drug responses associated with DNAJC14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VMVHPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6Y2X3
DnaJ homolog subfamily C member 14
LIG_APCC_ABBA_1
468:473
VMVHPD
APC,CDC20,FZR1
0.5215
More...