DegronMD

Uniprot ID: Q6Y2X3

Source protein: DnaJ homolog subfamily C member 14

Source gene: DNAJC14

Class: LIG_APCC_ABBA_1

Location: 468:473

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5215

ASA_SCORE: 66.1333

COIL: 0.4642

CONS_SCORE: 0.8391

DSS_SCORE: 0.4076

HELIX: 0.5333

FCONS_SCORE: 1.2466

RIG_SCORE: 0.7615

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V470A	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VMVHPD	LIG_APCC_ABBA_1	0.6936
p.V470A	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VMVHPD	LIG_APCC_ABBA_1	0.6936
p.N475S	TCGA-55-8204	LUAD	TCGA	VMVHPD	LIG_APCC_ABBA_1	0.2778
p.N475S	DO45322	LUAD	ICGC	VMVHPD	LIG_APCC_ABBA_1	0.2778
p.A462V	SIDM00901	Endometrial Carcinoma	GDSC	VMVHPD	LIG_APCC_ABBA_1	0.1667
p.A462V	AN3-CA	endometrium	COSMIC	VMVHPD	LIG_APCC_ABBA_1	0.1667
p.E481D	SIDM00282	Colorectal Carcinoma	GDSC	VMVHPD	LIG_APCC_ABBA_1	0.1111
p.E481D	CW-2	large_intestine	COSMIC	VMVHPD	LIG_APCC_ABBA_1	0.1111
p.E482Q	TCGA-44-2662	LUAD	TCGA	VMVHPD	LIG_APCC_ABBA_1	0.0833
p.E482Q	DO26290	LUAD	ICGC	VMVHPD	LIG_APCC_ABBA_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6Y2X3	DnaJ homolog subfamily C member 14	LIG_APCC_ABBA_1	468:473	VMVHPD	APC,CDC20,FZR1	0.5215	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons