DegronMD

Uniprot ID: Q96JK9

Source protein: Mastermind-like protein 3

Source gene: MAML3

Class: DEG_SCF_FBW7_1

Location: 33:40

E3 ligase: FBXW7

DEGRON score: 0.9595

ASA_SCORE: 73.0875

COIL: 0.8175

CONS_SCORE: 0.1505

DSS_SCORE: 0.5112

HELIX: 0.0314

FCONS_SCORE: 0.7563

RIG_SCORE: 0.6225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A50T	TCGA-BK-A13B	UCEC	TCGA	VNNTPNST	DEG_SCF_FBW7_1	0.0556
p.A50T	DO40825	UCEC	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.0556
p.I47M	DO49976	CESC	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.1389
p.R37Q	DO9010	COAD	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.7329
p.R37Q	DO222884	COCA	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.7329
p.A42V	DO234327	ESAD	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.2778
p.G27E	DO11106	GBM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.1667
p.R35Q	DO36881	READ	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.7329
p.F29L	DO220211	SARC	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.2222
p.K38N	DO37543	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.6918
p.G43W	DO37782	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.25
p.G43W	DO47497	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.25
p.M44R	DO51299	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JK9	Mastermind-like protein 3	DEG_SCF_FBW7_1	33:40	VNNTPNST	FBXW7	0.9595	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons