DegronMD - Q96JK9(MAML3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q853H	TCGA-A5-A0VQ	UCEC	TCGA	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1389
p.Q853H	DO42113	UCEC	ICGC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1389
p.A50T	TCGA-BK-A13B	UCEC	TCGA	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.0556
p.A50T	DO40825	UCEC	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.0556
p.A850T	TCGA-LI-A67I	SARC	TCGA	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.A850T	DO231953	LICA	ICGC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.A850T	DO220201	SARC	ICGC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.0556
p.S854L	DO218150	BRCA	ICGC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation rewiring degron network	0.1667
p.I47M	DO49976	CESC	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.1389
p.R37Q	DO9010	COAD	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation altering degron motif	0.7329
p.R37Q	DO222884	COCA	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation altering degron motif	0.7329
p.A42V	DO234327	ESAD	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.2778
p.G27E	DO11106	GBM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.1667
p.R35Q	DO36881	READ	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation altering degron motif	0.7329
p.F29L	DO220211	SARC	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.2222
p.K38N	DO37543	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation altering degron motif	0.6918
p.G43W	DO37782	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.25
p.G43W	DO47497	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.25
p.M44R	DO51299	SKCM	ICGC	VNNTPNST	DEG_SCF_FBW7_1	33:40	Mutation rewiring degron network	0.2222
p.T864M	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7423
p.T864M	SIDM01695	Acute Myeloid Leukemia	GDSC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7423
p.T864M	SLVL	haematopoietic and lymphoid tissue	COSMIC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7423
p.P860R	KG-1	haematopoietic and lymphoid tissue	COSMIC	PYSTT	DEG_SPOP_SBC_1	860:864	Mutation altering degron motif	0.7512

Kaplan plot for MAML3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAML3

UniProt ID: Q96JK9

Entrez ID: 55534

Protein name: Mastermind-like protein 3 (Mam-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAML3 in