DegronMD

Uniprot ID: Q96JK9

Source protein: Mastermind-like protein 3

Source gene: MAML3

Class: DEG_SPOP_SBC_1

Location: 860:864

E3 ligase: SPOP

DEGRON score: 0.8405

ASA_SCORE: 96.28

COIL: 0.9466

CONS_SCORE: 0.3093

DSS_SCORE: 0.565

HELIX: 0.0166

FCONS_SCORE: 1.0111

RIG_SCORE: 0.6583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q853H	TCGA-A5-A0VQ	UCEC	TCGA	PYSTT	DEG_SPOP_SBC_1	0.1389
p.Q853H	DO42113	UCEC	ICGC	PYSTT	DEG_SPOP_SBC_1	0.1389
p.A850T	TCGA-LI-A67I	SARC	TCGA	PYSTT	DEG_SPOP_SBC_1	0.0556
p.A850T	DO231953	LICA	ICGC	PYSTT	DEG_SPOP_SBC_1	0.0556
p.A850T	DO220201	SARC	ICGC	PYSTT	DEG_SPOP_SBC_1	0.0556
p.S854L	DO218150	BRCA	ICGC	PYSTT	DEG_SPOP_SBC_1	0.1667
p.T864M	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PYSTT	DEG_SPOP_SBC_1	0.7423
p.T864M	SIDM01695	Acute Myeloid Leukemia	GDSC	PYSTT	DEG_SPOP_SBC_1	0.7423
p.T864M	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PYSTT	DEG_SPOP_SBC_1	0.7423
p.P860R	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	PYSTT	DEG_SPOP_SBC_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JK9	Mastermind-like protein 3	DEG_SPOP_SBC_1	860:864	PYSTT	SPOP	0.8405	More...
Q9UI09	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	DEG_SPOP_SBC_1	126:130	PYSTT	SPOP	0.9202	More...
Q8N402	Putative uncharacterized protein LOC388882	DEG_SPOP_SBC_1	24:28	PYSTT	SPOP	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons