DegronMD

Uniprot ID: Q9UI09

Source protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Source gene: NDUFA12

Class: DEG_SPOP_SBC_1

Location: 126:130

E3 ligase: SPOP

DEGRON score: 0.9202

ASA_SCORE: 65.22

COIL: 0.8868

CONS_SCORE: 0.4803

DSS_SCORE: 0.3901

HELIX: 0.0348

FCONS_SCORE: 1.0143

RIG_SCORE: 0.8156

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E122Q	TCGA-37-3792	LUSC	TCGA	PYSTT	DEG_SPOP_SBC_1	0.2222
p.E122Q	DO27192	LUSC	ICGC	PYSTT	DEG_SPOP_SBC_1	0.2222
p.V117L	TCGA-86-8358	LUAD	TCGA	PYSTT	DEG_SPOP_SBC_1	0.0833
p.V117L	DO25471	LUAD	ICGC	PYSTT	DEG_SPOP_SBC_1	0.0833
p.P140S	TCGA-BA-4075	HNSC	TCGA	PYSTT	DEG_SPOP_SBC_1	0.0556
p.P140S	DO15775	HNSC	ICGC	PYSTT	DEG_SPOP_SBC_1	0.0556
p.N116D	DO231939	LICA	ICGC	PYSTT	DEG_SPOP_SBC_1	0.0556
p.T129N	DO229041	LICA	ICGC	PYSTT	DEG_SPOP_SBC_1	0.7055
p.S128A	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PYSTT	DEG_SPOP_SBC_1	0.7588
p.S128A	ACH-000392	Lung Cancer	CCLE	PYSTT	DEG_SPOP_SBC_1	0.7588
p.S128A	Calu-3	lung	COSMIC	PYSTT	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JK9	Mastermind-like protein 3	DEG_SPOP_SBC_1	860:864	PYSTT	SPOP	0.8405	More...
Q9UI09	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	DEG_SPOP_SBC_1	126:130	PYSTT	SPOP	0.9202	More...
Q8N402	Putative uncharacterized protein LOC388882	DEG_SPOP_SBC_1	24:28	PYSTT	SPOP	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons