DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PYSTT
Uniprot ID:
Q8N402
Source protein:
Putative uncharacterized protein LOC388882
Source gene:
-
Class:
DEG_SPOP_SBC_1
Location:
24:28
E3 ligase:
SPOP
DEGRON score:
0.9972
ASA_SCORE:
81.44
COIL:
0.8548
CONS_SCORE:
0
DSS_SCORE:
0.4376
HELIX:
0.0668
FCONS_SCORE:
0
RIG_SCORE:
0.7745
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with - mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PYSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96JK9
Mastermind-like protein 3
DEG_SPOP_SBC_1
860:864
PYSTT
SPOP
0.8405
More...
Q9UI09
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
DEG_SPOP_SBC_1
126:130
PYSTT
SPOP
0.9202
More...
Q8N402
Putative uncharacterized protein LOC388882
DEG_SPOP_SBC_1
24:28
PYSTT
SPOP
0.9972
More...