DegronMD

Uniprot ID: Q9P203

Source protein: BTB/POZ domain-containing protein 7

Source gene: BTBD7

Class: DEG_SCF_FBW7_2

Location: 735:742

E3 ligase: FBXW7

DEGRON score: 0.9048

ASA_SCORE: 80.5875

COIL: 0.783

CONS_SCORE: 0.3171

DSS_SCORE: 0.5559

HELIX: 0.1459

FCONS_SCORE: 0.839

RIG_SCORE: 0.6549

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A741P	TCGA-34-2604	LUSC	TCGA	VNSTPPAE	DEG_SCF_FBW7_2	0.6392
p.A741P	DO26433	LUSC	ICGC	VNSTPPAE	DEG_SCF_FBW7_2	0.6392
p.V735L	TCGA-64-1679	LUAD	TCGA	VNSTPPAE	DEG_SCF_FBW7_2	0.5654
p.V735L	DO26200	LUAD	ICGC	VNSTPPAE	DEG_SCF_FBW7_2	0.5654
p.G731E	TCGA-D3-A1Q8	SKCM	TCGA	VNSTPPAE	DEG_SCF_FBW7_2	0.2222
p.G731E	DO37446	SKCM	ICGC	VNSTPPAE	DEG_SCF_FBW7_2	0.2222
p.V735A	TCGA-F7-A624	HNSC	TCGA	VNSTPPAE	DEG_SCF_FBW7_2	0.6936
p.V735A	DO44440	HNSC	ICGC	VNSTPPAE	DEG_SCF_FBW7_2	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P203	BTB/POZ domain-containing protein 7	DEG_SCF_FBW7_2	735:742	VNSTPPAE	FBXW7	0.9048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons