DegronMD

Uniprot ID: Q9BZQ4

Source protein: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

Source gene: NMNAT2

Class: DEG_SCF_FBW7_1

Location: 117:123

E3 ligase: FBXW7

DEGRON score: 0.9546

ASA_SCORE: 57.1571

COIL: 0.7787

CONS_SCORE: 0.1801

DSS_SCORE: 0.3975

HELIX: 0.0644

FCONS_SCORE: 0.7894

RIG_SCORE: 0.7175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S115Y	TCGA-22-5472	LUSC	TCGA	VNTPSMT	DEG_SCF_FBW7_1	0.2778
p.S115Y	DO27421	LUSC	ICGC	VNTPSMT	DEG_SCF_FBW7_1	0.2778
p.G127R	TCGA-D9-A6E9	SKCM	TCGA	VNTPSMT	DEG_SCF_FBW7_1	0.2222
p.G127R	DO50289	SKCM	ICGC	VNTPSMT	DEG_SCF_FBW7_1	0.2222
p.E132K	DO224721	COCA	ICGC	VNTPSMT	DEG_SCF_FBW7_1	0.0833
p.P129A	DO228091	EOPC	ICGC	VNTPSMT	DEG_SCF_FBW7_1	0.1667
p.S121Y	DO231031	LUSC	ICGC	VNTPSMT	DEG_SCF_FBW7_1	0.6009
p.S115F	DO229459	SKCA	ICGC	VNTPSMT	DEG_SCF_FBW7_1	0.2778
p.T123K	ACH-002089	Lung Cancer	CCLE	VNTPSMT	DEG_SCF_FBW7_1	0.7306
p.T123K	201T	lung	COSMIC	VNTPSMT	DEG_SCF_FBW7_1	0.7306
p.T118K	201T	lung	COSMIC	VNTPSMT	DEG_SCF_FBW7_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZQ4	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2	DEG_SCF_FBW7_1	117:123	VNTPSMT	FBXW7	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons