DegronMD

Uniprot ID: Q9BZV3

Source protein: Interphotoreceptor matrix proteoglycan 2

Source gene: IMPG2

Class: LIG_APCC_ABBA_1

Location: 687:692

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.867

ASA_SCORE: 85.7667

COIL: 0.78

CONS_SCORE: 0.5727

DSS_SCORE: 0.5218

HELIX: 0.0292

FCONS_SCORE: 1.1835

RIG_SCORE: 0.7715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E680D	SIDM02059	Colorectal Carcinoma	GDSC	VPIFAD	LIG_APCC_ABBA_1	0.1389
p.A691P	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	VPIFAD	LIG_APCC_ABBA_1	0.6392
p.A691P	ACH-000733	Lung Cancer	CCLE	VPIFAD	LIG_APCC_ABBA_1	0.6392
p.A691P	NCI-H1838	lung	COSMIC	VPIFAD	LIG_APCC_ABBA_1	0.6392
p.D692N	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	VPIFAD	LIG_APCC_ABBA_1	0.6932
p.D692N	ACH-000694	Esophageal Cancer	CCLE	VPIFAD	LIG_APCC_ABBA_1	0.6932
p.D692N	TE-9	oesophagus	COSMIC	VPIFAD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZV3	Interphotoreceptor matrix proteoglycan 2	LIG_APCC_ABBA_1	687:692	VPIFAD	APC,CDC20,FZR1	0.867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons