DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VPLFPE
Uniprot ID:
O75113
Source protein:
NEDD4-binding protein 1
Source gene:
N4BP1
Class:
LIG_APCC_ABBA_1
Location:
518:523
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9908
ASA_SCORE:
79.9667
COIL:
0.8507
CONS_SCORE:
0.2354
DSS_SCORE:
0.6625
HELIX:
0.0502
FCONS_SCORE:
0.7258
RIG_SCORE:
0.6643
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with N4BP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPLFPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75113
NEDD4-binding protein 1
LIG_APCC_ABBA_1
518:523
VPLFPE
APC,CDC20,FZR1
0.9908
More...