DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: LIG_APCC_ABBA_1

Location: 1084:1089

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 77.5833

COIL: 0.702

CONS_SCORE: 0.3209

DSS_SCORE: 0.3509

HELIX: 0.2728

FCONS_SCORE: 1.1326

RIG_SCORE: 0.7726

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1090H	TCGA-D8-A27M	BRCA	TCGA	VPMYEE	LIG_APCC_ABBA_1	0.3056
p.Q1090H	DO1380	BRCA	ICGC	VPMYEE	LIG_APCC_ABBA_1	0.3056
p.E1089D	SIDM00845	Burkitt's Lymphoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.5647
p.R1077H	SIDM01145	Gastric Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077H	SIDM01181	Hepatocellular Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077H	SIDM01368	Gastric Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077H	SIDM01394	Kidney Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077H	SIDM01574	Plasma Cell Myeloma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077S	SIDM00097	Breast Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077S	SIDM00861	Ovarian Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077S	SIDM01613	Colorectal Carcinoma	GDSC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077S	ES-2	ovary	COSMIC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.R1077S	T47D	breast	COSMIC	VPMYEE	LIG_APCC_ABBA_1	0.1389
p.A1078T	ACH-000674	Gastric Cancer	CCLE	VPMYEE	LIG_APCC_ABBA_1	0.1667
p.A1078T	NUGC-4	stomach	COSMIC	VPMYEE	LIG_APCC_ABBA_1	0.1667
p.Y1099H	GP5d	large_intestine	COSMIC	VPMYEE	LIG_APCC_ABBA_1	0.0556
p.A1074T	NUGC-4	stomach	COSMIC	VPMYEE	LIG_APCC_ABBA_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	LIG_APCC_ABBA_1	1084:1089	VPMYEE	APC,CDC20,FZR1	0.9987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons