DegronMD

Uniprot ID: Q96EK7

Source protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Source gene: FAM120B

Class: LIG_APCC_ABBA_1

Location: 425:430

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9859

ASA_SCORE: 100.0667

COIL: 0.9398

CONS_SCORE: 0.4904

DSS_SCORE: 0.699

HELIX: 0.0245

FCONS_SCORE: 1.0245

RIG_SCORE: 0.6891

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M427I	TCGA-LN-A7HV	ESCA	TCGA	VPMYTD	LIG_APCC_ABBA_1	0.6507
p.D418G	DO48361	BLCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO228483	BRCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO224685	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO224701	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO229505	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO50997	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO229253	THCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.D418G	DO229227	THCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1389
p.S431P	DO1076	BRCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.S431P	DO224668	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.S431P	DO224661	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.S431P	DO222888	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.A433P	DO230334	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.A433P	DO224620	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.A433P	DO222804	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.A433P	DO222856	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.A433P	DO229505	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.A433P	DO51021	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.P421S	DO224786	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.P421S	DO45357	LUAD	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.Y428C	DO229010	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7087
p.Y428C	DO229003	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7087
p.Y428C	DO229005	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7087
p.A433S	DO228571	GACA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.E436G	DO50793	LIRI	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.E436G	ACH-000209	Bile Duct Cancer	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.E436G	ACH-000467	Colon/Colorectal Cancer	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.E436G	HCC-56	large_intestine	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.T416R	SIDM00367	Small Cell Lung Carcinoma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM00235	Kidney Carcinoma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM00360	Other Solid Cancers	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM00970	Bladder Carcinoma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM00380	Acute Myeloid Leukemia	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM00579	Neuroblastoma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM01609	Endometrial Carcinoma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM01608	Endometrial Carcinoma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM00166	Other Solid Cancers	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SIDM01756	Chronic Myelogenous Leukemia	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	QGP-1	pancreas	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	NB(TU)1-10	autonomic_ganglia	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	SBC-3	lung	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	DSH1	urinary_tract	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.T416R	RCC10RGB	kidney	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0833
p.Q434R	SIDM00380	Acute Myeloid Leukemia	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.Q434R	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.E420V	ACH-000389	Brain Cancer	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	ACH-002462	Non-Cancerous	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	ACH-002463	Non-Cancerous	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	ACH-002464	Non-Cancerous	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	ACH-002465	Non-Cancerous	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	ACH-002466	Non-Cancerous	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	ACH-002467	Non-Cancerous	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.E420V	H4	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	S-117	soft_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	LC-2-ad	lung	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	NCI-H2291	lung	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	ABC-1	lung	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	SW962	vulva	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	huH-1	liver	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	VMRC-RCZ	kidney	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	LU-135	lung	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	SAS	upper_aerodigestive_tract	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	D-392MG	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	NCI-H1975	lung	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	CAS-1	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	FU-OV-1	ovary	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	TE-5	oesophagus	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	U-118-MG	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.S420A	JHH-4	liver	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944
p.C415Y	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0556
p.C415Y	OVISE	ovary	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.0556
p.Q423R	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.2778
p.E432V	H4	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPMYTD

Degron related mutations and impact score

Drug responses associated with FAM120B mutations

All proteins holding degron of VPMYTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	LIG_APCC_ABBA_1	425:430	VPMYTD	APC,CDC20,FZR1	0.9859	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	LIG_APCC_ABBA_1	437:442	VPMYTD	APC,CDC20,FZR1	0.8922	More...