DegronMD

Uniprot ID: Q96EK7

Source protein: Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Source gene: FAM120B

Class: LIG_APCC_ABBA_1

Location: 437:442

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8922

ASA_SCORE: 100.2167

COIL: 0.9338

CONS_SCORE: 0.4589

DSS_SCORE: 0.7437

HELIX: 0.024

FCONS_SCORE: 0.9313

RIG_SCORE: 0.689

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y452H	TCGA-06-5416	GBM	TCGA	VPMYTD	LIG_APCC_ABBA_1	0.5
p.D442Y	TCGA-AP-A0LM	UCEC	TCGA	VPMYTD	LIG_APCC_ABBA_1	0.7325
p.S431P	DO1076	BRCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.S431P	DO224668	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.S431P	DO224661	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.S431P	DO222888	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.A433P	DO230334	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.A433P	DO224620	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.A433P	DO222804	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.A433P	DO222856	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.A433P	DO229505	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.A433P	DO51021	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.D442G	DO224668	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7198
p.D442G	DO224661	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7198
p.D442G	DO222790	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7198
p.D442G	DO222888	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7198
p.D442G	DO35964	PBCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.7198
p.P445A	DO222888	COCA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.A433S	DO228571	GACA	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.2222
p.Y452C	DO229505	LAML	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.5
p.E436G	DO50793	LIRI	ICGC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.E436G	ACH-000209	Bile Duct Cancer	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.E436G	ACH-000467	Colon/Colorectal Cancer	CCLE	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.E436G	HCC-56	large_intestine	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.E443V	SIDM00852	Glioma	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.E443V	H4	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.3056
p.Q434R	SIDM00380	Acute Myeloid Leukemia	GDSC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.Q434R	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.25
p.E448G	HCC-56	large_intestine	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1667
p.E432V	H4	central_nervous_system	COSMIC	VPMYTD	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPMYTD

Degron related mutations and impact score

Drug responses associated with FAM120B mutations

All proteins holding degron of VPMYTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	LIG_APCC_ABBA_1	425:430	VPMYTD	APC,CDC20,FZR1	0.9859	More...
Q96EK7	Constitutive coactivator of peroxisome proliferator-activated receptor gamma	LIG_APCC_ABBA_1	437:442	VPMYTD	APC,CDC20,FZR1	0.8922	More...