DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 260:267

E3 ligase: FBXW7

DEGRON score: 0.9899

ASA_SCORE: 87.925

COIL: 0.9611

CONS_SCORE: 0.7728

DSS_SCORE: 0.7606

HELIX: 0.0188

FCONS_SCORE: 1.6336

RIG_SCORE: 0.5738

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T267A	DO222720	ESCA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.7139
p.P264T	SIDM00965	Small Cell Lung Carcinoma	GDSC	VPPTPSAT	DEG_SCF_FBW7_1	0.7031
p.P264T	ACH-000800	Lung Cancer	CCLE	VPPTPSAT	DEG_SCF_FBW7_1	0.7031
p.P264T	NCI-H446	lung	COSMIC	VPPTPSAT	DEG_SCF_FBW7_1	0.7031
p.V260A	DO220863	MELA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.6936
p.V260A	DO218872	SKCA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.6936
p.P261L	TCGA-WS-AB45	COAD	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.6471
p.P261L	DO51734	COAD	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.6471
p.A259D	TCGA-E7-A4IJ	BLCA	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.3056
p.A259D	DO453	BLCA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.3056
p.D270Y	TCGA-50-6593	LUAD	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.25
p.D270Y	TCGA-AX-A05Z	UCEC	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.25
p.D270Y	DO24100	LUAD	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.25
p.D270Y	DO40884	UCEC	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.25
p.D270A	DO46374	OV	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.25
p.P255R	DO225002	BRCA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.1944
p.P254Q	TCGA-A8-A07J	BRCA	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.1667
p.P254S	DO222550	MELA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.1667
p.A274T	TCGA-29-1702	OV	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A274T	DO11441	GBM	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A274T	DO29528	OV	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A274T	DO33084	PACA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A274T	SIDM02057	Colorectal Carcinoma	GDSC	VPPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A253T	TCGA-HQ-A5ND	BLCA	TCGA	VPPTPSAT	DEG_SCF_FBW7_1	0.1389
p.A253T	DO51899	BLCA	ICGC	VPPTPSAT	DEG_SCF_FBW7_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	260:267	VPPTPSAT	FBXW7	0.9899	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons