DegronMD

Uniprot ID: Q9BZJ8

Source protein: G-protein coupled receptor 61

Source gene: GPR61

Class: DEG_SCF_FBW7_1

Location: 19:26

E3 ligase: FBXW7

DEGRON score: 0.9865

ASA_SCORE: 80.5875

COIL: 0.9483

CONS_SCORE: 0.316

DSS_SCORE: 0.6738

HELIX: 0.0176

FCONS_SCORE: 1.0671

RIG_SCORE: 0.5776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9L	TCGA-60-2698	LUSC	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.0556
p.S9L	DO26469	LUSC	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.0556
p.P23Q	TCGA-80-5608	LUAD	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.7035
p.P23Q	DO23693	LUAD	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.7035
p.P32L	TCGA-97-8172	LUAD	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.1667
p.P32L	TCGA-AA-3492	COAD	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.1667
p.P32L	DO8224	COAD	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.1667
p.P32L	DO26384	LUAD	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.1667
p.S13T	TCGA-AX-A06F	UCEC	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.1667
p.S13T	DO41752	UCEC	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.1667
p.G35W	TCGA-BQ-7044	KIRP	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.0833
p.G35W	DO20942	KIRP	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.0833
p.A28S	TCGA-CR-7395	HNSC	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.2778
p.A28S	DO14274	HNSC	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.2778
p.P25L	TCGA-D9-A149	SKCM	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.6471
p.P25L	DO37420	SKCM	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.6471
p.P20H	TCGA-DJ-A2QB	THCA	TCGA	VPQTPGPS	DEG_SCF_FBW7_1	0.6583
p.P20H	DO39421	THCA	ICGC	VPQTPGPS	DEG_SCF_FBW7_1	0.6583
p.R18S	SIDM01770	Gastric Carcinoma	GDSC	VPQTPGPS	DEG_SCF_FBW7_1	0.3056
p.Q21H	ACH-002192	Kidney Cancer	CCLE	VPQTPGPS	DEG_SCF_FBW7_1	0.647
p.Q21H	RCC-MF	kidney	COSMIC	VPQTPGPS	DEG_SCF_FBW7_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZJ8	G-protein coupled receptor 61	DEG_SCF_FBW7_1	19:26	VPQTPGPS	FBXW7	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons