DegronMD

Uniprot ID: P23582

Source protein: C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]

Source gene: NPPC

Class: DEG_SCF_FBW7_2

Location: 31:38

E3 ligase: FBXW7

DEGRON score: 0.9661

ASA_SCORE: 78.35

COIL: 0.6685

CONS_SCORE: 0.603

DSS_SCORE: 0.7791

HELIX: 0.307

FCONS_SCORE: 1.0561

RIG_SCORE: 0.6306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P35S	DO50970	LICA	ICGC	VPRTPPAE	DEG_SCF_FBW7_2	0.6752
p.A27V	DO229192	THCA	ICGC	VPRTPPAE	DEG_SCF_FBW7_2	0.2222
p.A41T	DO229218	THCA	ICGC	VPRTPPAE	DEG_SCF_FBW7_2	0.25
p.P36Q	DO229227	THCA	ICGC	VPRTPPAE	DEG_SCF_FBW7_2	0.5924
p.Q44R	SIDM00305	Ovarian Carcinoma	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.1667
p.Q44R	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.1667
p.Q44R	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.1667
p.Q44R	SIDM01368	Gastric Carcinoma	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.1667
p.Q44R	SIDM01658	Unknown	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.1667
p.Q44R	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.1667
p.A27S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	VPRTPPAE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23582	C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]	DEG_SCF_FBW7_2	31:38	VPRTPPAE	FBXW7	0.9661	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons