DegronMD

Uniprot ID: O15211

Source protein: Ral guanine nucleotide dissociation stimulator-like 2

Source gene: RGL2

Class: DEG_SCF_FBW7_1

Location: 542:548

E3 ligase: FBXW7

DEGRON score: 0.9685

ASA_SCORE: 74.6

COIL: 0.9011

CONS_SCORE: 0.2296

DSS_SCORE: 0.4726

HELIX: 0.0273

FCONS_SCORE: 0.9867

RIG_SCORE: 0.7415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G555R	TCGA-57-1993	OV	TCGA	VPTPLVS	DEG_SCF_FBW7_1	0.1389
p.G555R	DO30910	OV	ICGC	VPTPLVS	DEG_SCF_FBW7_1	0.1389
p.W533R	TCGA-60-2698	LUSC	TCGA	VPTPLVS	DEG_SCF_FBW7_1	0.0833
p.W533R	DO26469	LUSC	ICGC	VPTPLVS	DEG_SCF_FBW7_1	0.0833
p.S553N	TCGA-A5-A1OF	UCEC	TCGA	VPTPLVS	DEG_SCF_FBW7_1	0.1944
p.S553N	DO42568	UCEC	ICGC	VPTPLVS	DEG_SCF_FBW7_1	0.1944
p.D557N	TCGA-AP-A1DV	UCEC	TCGA	VPTPLVS	DEG_SCF_FBW7_1	0.0833
p.D557N	DO43186	UCEC	ICGC	VPTPLVS	DEG_SCF_FBW7_1	0.0833
p.C549R	TCGA-BS-A0TA	UCEC	TCGA	VPTPLVS	DEG_SCF_FBW7_1	0.3056
p.C549R	DO43298	UCEC	ICGC	VPTPLVS	DEG_SCF_FBW7_1	0.3056
p.G541V	TCGA-HE-7130	KIRP	TCGA	VPTPLVS	DEG_SCF_FBW7_1	0.3056
p.G541V	DO20776	KIRP	ICGC	VPTPLVS	DEG_SCF_FBW7_1	0.3056
p.P545R	SIDM00292	Small Cell Lung Carcinoma	GDSC	VPTPLVS	DEG_SCF_FBW7_1	0.7512
p.P545R	ACH-002077	Lung Cancer	CCLE	VPTPLVS	DEG_SCF_FBW7_1	0.7512
p.P545R	LU-165	lung	COSMIC	VPTPLVS	DEG_SCF_FBW7_1	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15211	Ral guanine nucleotide dissociation stimulator-like 2	DEG_SCF_FBW7_1	542:548	VPTPLVS	FBXW7	0.9685	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons