DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPTPNIT
Uniprot ID:
Q8NDA2
Source protein:
Hemicentin-2
Source gene:
HMCN2
Class:
DEG_SCF_FBW7_1
Location:
1558:1564
E3 ligase:
FBXW7
DEGRON score:
0.5375
ASA_SCORE:
58.4
COIL:
0.5367
CONS_SCORE:
0.5007
DSS_SCORE:
0.2065
HELIX:
0.004
FCONS_SCORE:
0.998
RIG_SCORE:
0.8113
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HMCN2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPTPNIT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDA2
Hemicentin-2
DEG_SCF_FBW7_1
1558:1564
VPTPNIT
FBXW7
0.5375
More...