DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VPTPQVE
Uniprot ID:
Q8NDA2
Source protein:
Hemicentin-2
Source gene:
HMCN2
Class:
DEG_SCF_FBW7_2
Location:
1464:1470
E3 ligase:
FBXW7
DEGRON score:
0.5544
ASA_SCORE:
64.1429
COIL:
0.564
CONS_SCORE:
0.4866
DSS_SCORE:
0.4484
HELIX:
0.0054
FCONS_SCORE:
1.0143
RIG_SCORE:
0.7479
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with HMCN2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VPTPQVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDA2
Hemicentin-2
DEG_SCF_FBW7_2
1464:1470
VPTPQVE
FBXW7
0.5544
More...