DegronMD

Uniprot ID: Q9UHR4

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Source gene: BAIAP2L1

Class: DEG_SCF_FBW7_1

Location: 410:416

E3 ligase: FBXW7

DEGRON score: 0.8985

ASA_SCORE: 95.3857

COIL: 0.9774

CONS_SCORE: 0.617

DSS_SCORE: 0.5248

HELIX: 0.0084

FCONS_SCORE: 1.4362

RIG_SCORE: 0.683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T412M	TCGA-AJ-A3EK	UCEC	TCGA	VPTPSPT	DEG_SCF_FBW7_1	0.8534
p.T412M	DO233737	GACA	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.8534
p.T412M	DO41584	UCEC	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.8534
p.S422N	TCGA-BR-8487	STAD	TCGA	VPTPSPT	DEG_SCF_FBW7_1	0.6111
p.S422N	DO47867	STAD	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.6111
p.P415H	TCGA-EE-A2GK	SKCM	TCGA	VPTPSPT	DEG_SCF_FBW7_1	0.6583
p.P415H	DO37738	SKCM	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.6583
p.V418M	TCGA-XK-AAIW	PRAD	TCGA	VPTPSPT	DEG_SCF_FBW7_1	0.2778
p.V418M	DO51407	PRAD	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.2778
p.L400M	DO229025	LICA	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.0556
p.L426S	DO231754	LINC	ICGC	VPTPSPT	DEG_SCF_FBW7_1	0.0556
p.V424M	SIDM02013	Colorectal Carcinoma	GDSC	VPTPSPT	DEG_SCF_FBW7_1	0.1111
p.N403D	SIDM00267	Biliary Tract Carcinoma	GDSC	VPTPSPT	DEG_SCF_FBW7_1	0.1389
p.N403D	ACH-002044	Head and Neck Cancer	CCLE	VPTPSPT	DEG_SCF_FBW7_1	0.1389
p.N403D	ACH-002312	Gallbladder Cancer	CCLE	VPTPSPT	DEG_SCF_FBW7_1	0.1389
p.N403D	TGBC24TKB	biliary_tract	COSMIC	VPTPSPT	DEG_SCF_FBW7_1	0.1389
p.E402Q	ACH-000923	Lymphoma	CCLE	VPTPSPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	DEG_SCF_FBW7_1	410:416	VPTPSPT	FBXW7	0.8985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons