DegronMD

Uniprot ID: O76041

Source protein: Nebulette

Source gene: NEBL

Class: LIG_APCC_ABBA_1

Location: 3:8

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8451

ASA_SCORE: 79.25

COIL: 0.4818

CONS_SCORE: 0.398

DSS_SCORE: 0.7871

HELIX: 0.4863

FCONS_SCORE: 0.9978

RIG_SCORE: 0.7999

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D8Y	TCGA-55-A490	LUAD	TCGA	VPVFED	LIG_APCC_ABBA_1	0.7325
p.D8Y	DO229060	LICA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.7325
p.D8Y	DO24596	LUAD	ICGC	VPVFED	LIG_APCC_ABBA_1	0.7325
p.I18M	TCGA-AN-A0AM	BRCA	TCGA	VPVFED	LIG_APCC_ABBA_1	0.0556
p.I18M	DO4191	BRCA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.0556
p.D11Y	TCGA-BS-A0UF	UCEC	TCGA	VPVFED	LIG_APCC_ABBA_1	0.25
p.D11Y	DO8264	COAD	ICGC	VPVFED	LIG_APCC_ABBA_1	0.25
p.D11Y	DO41488	UCEC	ICGC	VPVFED	LIG_APCC_ABBA_1	0.25
p.E14K	TCGA-C8-A1HM	BRCA	TCGA	VPVFED	LIG_APCC_ABBA_1	0.1667
p.E14K	DO3904	BRCA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.1667
p.E14G	TCGA-EO-A22X	UCEC	TCGA	VPVFED	LIG_APCC_ABBA_1	0.1667
p.E14G	DO43907	UCEC	ICGC	VPVFED	LIG_APCC_ABBA_1	0.1667
p.E15K	TCGA-FW-A3R5	SKCM	TCGA	VPVFED	LIG_APCC_ABBA_1	0.1389
p.E15K	DO37406	SKCM	ICGC	VPVFED	LIG_APCC_ABBA_1	0.1389
p.A6S	DO225004	BRCA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.7588
p.E16K	DO230326	COCA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.1111
p.Q4K	DO229027	LICA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.6944
p.F4L	DO26469	LUSC	ICGC	VPVFED	LIG_APCC_ABBA_1	0.6981
p.E12K	DO222546	MELA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.2222
p.E12K	DO222653	MELA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.2222
p.E12D	DO46368	OV	ICGC	VPVFED	LIG_APCC_ABBA_1	0.2222
p.V18I	DO218861	SKCA	ICGC	VPVFED	LIG_APCC_ABBA_1	0.0556
p.K10N	DO41758	UCEC	ICGC	VPVFED	LIG_APCC_ABBA_1	0.2778
p.P4L	SIDM00454	Rhabdomyosarcoma	GDSC	VPVFED	LIG_APCC_ABBA_1	0.6471
p.P4L	SIDM00633	Breast Carcinoma	GDSC	VPVFED	LIG_APCC_ABBA_1	0.6471
p.P4L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VPVFED	LIG_APCC_ABBA_1	0.6471
p.D8N	SIDM00003	Melanoma	GDSC	VPVFED	LIG_APCC_ABBA_1	0.6932
p.D8N	SIDM00312	Plasma Cell Myeloma	GDSC	VPVFED	LIG_APCC_ABBA_1	0.6932
p.D8N	ACH-000183	Myeloma	CCLE	VPVFED	LIG_APCC_ABBA_1	0.6932
p.D8N	ACH-002159	Skin Cancer	CCLE	VPVFED	LIG_APCC_ABBA_1	0.6932
p.D8N	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	VPVFED	LIG_APCC_ABBA_1	0.6932
p.D8N	M14	skin	COSMIC	VPVFED	LIG_APCC_ABBA_1	0.6932
p.V5A	SIDM00254	Neuroblastoma	GDSC	VPVFED	LIG_APCC_ABBA_1	0.6936
p.V5A	ACH-002283	Neuroblastoma	CCLE	VPVFED	LIG_APCC_ABBA_1	0.6936
p.V5A	NB5	autonomic_ganglia	COSMIC	VPVFED	LIG_APCC_ABBA_1	0.6936
p.C5R	ACH-000971	Colon/Colorectal Cancer	CCLE	VPVFED	LIG_APCC_ABBA_1	0.8301
p.C5R	HCT-116	large_intestine	COSMIC	VPVFED	LIG_APCC_ABBA_1	0.8301
p.P14S	ACH-001119	Lymphoma	CCLE	VPVFED	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPVFED

Degron related mutations and impact score

Drug responses associated with NEBL mutations

All proteins holding degron of VPVFED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76041	Nebulette	LIG_APCC_ABBA_1	3:8	VPVFED	APC,CDC20,FZR1	0.8451	More...