DegronMD

Uniprot ID: Q8TD94

Source protein: Krueppel-like factor 14

Source gene: KLF14

Class: DEG_SCF_FBW7_2

Location: 122:128

E3 ligase: FBXW7

DEGRON score: 0.5173

ASA_SCORE: 82.6429

COIL: 0.8851

CONS_SCORE: 0.3473

DSS_SCORE: 0.3925

HELIX: 0.041

FCONS_SCORE: 0.9194

RIG_SCORE: 0.7282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A132T	DO232761	PBCA	ICGC	VQTPCSE	DEG_SCF_FBW7_2	0.2222
p.T124P	DO218862	SKCA	ICGC	VQTPCSE	DEG_SCF_FBW7_2	0.7031
p.D116N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VQTPCSE	DEG_SCF_FBW7_2	0.1667
p.P131S	ACH-001956	Bone Cancer	CCLE	VQTPCSE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD94	Krueppel-like factor 14	DEG_SCF_FBW7_2	122:128	VQTPCSE	FBXW7	0.5173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons