DegronMD

Uniprot ID: Q6PML9

Source protein: Zinc transporter 9

Source gene: SLC30A9

Class: DEG_SCF_FBW7_1

Location: 291:297

E3 ligase: FBXW7

DEGRON score: 0.8265

ASA_SCORE: 76.6143

COIL: 0.9327

CONS_SCORE: 0.5867

DSS_SCORE: 0.3246

HELIX: 0.0391

FCONS_SCORE: 0.9182

RIG_SCORE: 0.6833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M305K	TCGA-77-A5G1	LUSC	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.1111
p.M305K	DO50096	LUSC	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.1111
p.H298Y	TCGA-A8-A09A	BRCA	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.3056
p.H298Y	DO2955	BRCA	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.3056
p.R306C	TCGA-AA-A01R	COAD	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.R306C	TCGA-BH-A0HA	BRCA	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.R306C	DO1658	BRCA	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.R306C	DO7934	COAD	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.R306C	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.R306C	ACH-000628	Lung Cancer	CCLE	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.R306C	NCI-H596	lung	COSMIC	VQTPDPS	DEG_SCF_FBW7_1	0.0833
p.P299L	TCGA-AJ-A3BG	UCEC	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.2778
p.P299L	DO42633	UCEC	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.2778
p.G281V	TCGA-AX-A1CE	UCEC	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.0556
p.G281V	DO42280	UCEC	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.0556
p.H298R	TCGA-EE-A3JI	SKCM	TCGA	VQTPDPS	DEG_SCF_FBW7_1	0.3056
p.H298R	DO47268	SKCM	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.3056
p.Y307H	DO222877	COCA	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.0556
p.D295V	DO36556	READ	ICGC	VQTPDPS	DEG_SCF_FBW7_1	0.6674

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PML9	Zinc transporter 9	DEG_SCF_FBW7_1	291:297	VQTPDPS	FBXW7	0.8265	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons