DegronMD

Uniprot ID: Q96FL9

Source protein: Polypeptide N-acetylgalactosaminyltransferase 14

Source gene: GALNT14

Class: DEG_SCF_FBW7_1

Location: 39:45

E3 ligase: FBXW7

DEGRON score: 0.8192

ASA_SCORE: 79.7571

COIL: 0.885

CONS_SCORE: 0.4387

DSS_SCORE: 0.506

HELIX: 0.0349

FCONS_SCORE: 0.8077

RIG_SCORE: 0.7184

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V33L	TCGA-05-4420	LUAD	TCGA	VQTPKPS	DEG_SCF_FBW7_1	0.1667
p.V33L	DO24675	LUAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1667
p.R29S	TCGA-28-5211	GBM	TCGA	VQTPKPS	DEG_SCF_FBW7_1	0.0556
p.R29S	DO11016	GBM	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.0556
p.R47Q	DO8063	COAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.2778
p.A47T	DO8192	COAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.2778
p.D46N	DO8400	COAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.3056
p.G53A	DO227987	COCA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1111
p.S46P	DO50337	ESAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.3056
p.W49R	DO234333	ESAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.2222
p.S54R	DO233618	GACA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.0833
p.P37T	DO229027	LICA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.2778
p.P34T	DO229036	LICA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1944
p.V33M	DO229177	LMS	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1667
p.S49R	DO25927	LUAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.2222
p.S53F	DO220878	MELA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1111
p.S45L	DO220897	MELA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.7667
p.S45L	DO223907	SKCM	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.7667
p.S45L	DO38201	STAD	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.7667
p.S45L	DO41542	UCEC	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.7667
p.D51N	DO218848	SKCA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1667
p.D51N	DO38123	SKCM	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.1667
p.Q46P	DO48770	SKCM	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.3056
p.P44S	DO229259	THCA	ICGC	VQTPKPS	DEG_SCF_FBW7_1	0.5641
p.A52S	SIDM00555	Glioblastoma	GDSC	VQTPKPS	DEG_SCF_FBW7_1	0.1389
p.A52S	KS-1	central_nervous_system	COSMIC	VQTPKPS	DEG_SCF_FBW7_1	0.1389
p.L52P	SIDM01588	Endometrial Carcinoma	GDSC	VQTPKPS	DEG_SCF_FBW7_1	0.1389
p.L52P	ACH-000993	Endometrial/Uterine Cancer	CCLE	VQTPKPS	DEG_SCF_FBW7_1	0.1389
p.K46N	639-V	urinary_tract	COSMIC	VQTPKPS	DEG_SCF_FBW7_1	0.3056
p.R39W	SNU-1040	large_intestine	COSMIC	VQTPKPS	DEG_SCF_FBW7_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FL9	Polypeptide N-acetylgalactosaminyltransferase 14	DEG_SCF_FBW7_1	39:45	VQTPKPS	FBXW7	0.8192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQTPKPS

Degron related mutations and impact score

Drug responses associated with GALNT14 mutations

All proteins holding degron of VQTPKPS