DegronMD

Uniprot ID: Q9H6R0

Source protein: ATP-dependent RNA helicase DHX33

Source gene: DHX33

Class: DEG_APCC_DBOX_1

Location: 595:603

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6987

ASA_SCORE: 37.7

COIL: 0.0047

CONS_SCORE: 0.5301

DSS_SCORE: 0.1065

HELIX: 0.9949

FCONS_SCORE: 1.1921

RIG_SCORE: 0.9244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T590M	TCGA-AZ-4614	COAD	TCGA	VRAQLRDIC	DEG_APCC_DBOX_1	0.1944
p.T590M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VRAQLRDIC	DEG_APCC_DBOX_1	0.1944
p.T590M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VRAQLRDIC	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H6R0	ATP-dependent RNA helicase DHX33	DEG_APCC_DBOX_1	595:603	VRAQLRDIC	APC,CDC20,FZR1	0.6987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons