DegronMD - Q9H6R0(DHX33)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E581D	TCGA-AG-A002	READ	TCGA	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.6758
p.E581D	TCGA-BT-A3PJ	BLCA	TCGA	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.6758
p.T590M	TCGA-AZ-4614	COAD	TCGA	VRAQLRDIC	DEG_APCC_DBOX_1	595:603	Mutation rewiring degron network	0.1944
p.T590M	TCGA-AZ-4614	COAD	TCGA	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.T590M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	VRAQLRDIC	DEG_APCC_DBOX_1	595:603	Mutation rewiring degron network	0.1944
p.T590M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.T590M	MN-60	haematopoietic and lymphoid tissue	COSMIC	VRAQLRDIC	DEG_APCC_DBOX_1	595:603	Mutation rewiring degron network	0.1944
p.T590M	MN-60	haematopoietic and lymphoid tissue	COSMIC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.L572V	SIDM00625	Other Sarcomas	GDSC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.L572V	MES-SA	soft tissue	COSMIC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1389
p.N571D	SIDM00625	Other Sarcomas	GDSC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1111
p.N571D	MES-SA	soft tissue	COSMIC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation rewiring degron network	0.1111
p.F583Y	SIDM01045	Endometrial Carcinoma	GDSC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.6417
p.F583Y	EN	endometrium	COSMIC	CKENF	DEG_APCC_KENBOX_2	579:583	Mutation altering degron motif	0.6417

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons