DegronMD

Uniprot ID: Q9H6R0

Source protein: ATP-dependent RNA helicase DHX33

Source gene: DHX33

Class: DEG_APCC_KENBOX_2

Location: 579:583

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5266

ASA_SCORE: 80.94

COIL: 0.4328

CONS_SCORE: 0.5333

DSS_SCORE: 0.1989

HELIX: 0.5582

FCONS_SCORE: 1.1875

RIG_SCORE: 0.893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E581D	TCGA-AG-A002	READ	TCGA	CKENF	DEG_APCC_KENBOX_2	0.6758
p.E581D	TCGA-BT-A3PJ	BLCA	TCGA	CKENF	DEG_APCC_KENBOX_2	0.6758
p.T590M	TCGA-AZ-4614	COAD	TCGA	CKENF	DEG_APCC_KENBOX_2	0.1389
p.T590M	SIDM00438	B-Lymphoblastic Leukemia	GDSC	CKENF	DEG_APCC_KENBOX_2	0.1389
p.T590M	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	CKENF	DEG_APCC_KENBOX_2	0.1389
p.L572V	SIDM00625	Other Sarcomas	GDSC	CKENF	DEG_APCC_KENBOX_2	0.1389
p.L572V	MES-SA	soft_tissue	COSMIC	CKENF	DEG_APCC_KENBOX_2	0.1389
p.N571D	SIDM00625	Other Sarcomas	GDSC	CKENF	DEG_APCC_KENBOX_2	0.1111
p.N571D	MES-SA	soft_tissue	COSMIC	CKENF	DEG_APCC_KENBOX_2	0.1111
p.F583Y	SIDM01045	Endometrial Carcinoma	GDSC	CKENF	DEG_APCC_KENBOX_2	0.6417
p.F583Y	EN	endometrium	COSMIC	CKENF	DEG_APCC_KENBOX_2	0.6417

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZY0	Nuclear RNA export factor 2	DEG_APCC_KENBOX_2	378:382	CKENF	APC,CDC20,FZR1	0.6147	More...
Q9H6R0	ATP-dependent RNA helicase DHX33	DEG_APCC_KENBOX_2	579:583	CKENF	APC,CDC20,FZR1	0.5266	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons