DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
CKENF
Uniprot ID:
Q9GZY0
Source protein:
Nuclear RNA export factor 2
Source gene:
NXF2; NXF2B
Class:
DEG_APCC_KENBOX_2
Location:
378:382
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6147
ASA_SCORE:
51.18
COIL:
0.6966
CONS_SCORE:
0.4387
DSS_SCORE:
0.398
HELIX:
0.1352
FCONS_SCORE:
1.1057
RIG_SCORE:
0.7717
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S385Y
TCGA-A5-A0G2
UCEC
TCGA
CKENF
DEG_APCC_KENBOX_2
0.25
p.S385Y
DO41235
UCEC
ICGC
CKENF
DEG_APCC_KENBOX_2
0.25
Drug responses associated with NXF2; NXF2B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of CKENF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9GZY0
Nuclear RNA export factor 2
DEG_APCC_KENBOX_2
378:382
CKENF
APC,CDC20,FZR1
0.6147
More...
Q9H6R0
ATP-dependent RNA helicase DHX33
DEG_APCC_KENBOX_2
579:583
CKENF
APC,CDC20,FZR1
0.5266
More...