DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VRASLQKVS
Uniprot ID:
Q5R372
Source protein:
Rab GTPase-activating protein 1-like
Source gene:
RABGAP1L
Class:
DEG_APCC_DBOX_1
Location:
3:11
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6325
ASA_SCORE:
90.5333
COIL:
0.6091
CONS_SCORE:
0.2468
DSS_SCORE:
0.6076
HELIX:
0.272
FCONS_SCORE:
1.0048
RIG_SCORE:
0.7316
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with RABGAP1L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRASLQKVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5R372
Rab GTPase-activating protein 1-like
DEG_APCC_DBOX_1
3:11
VRASLQKVS
APC,CDC20,FZR1
0.6325
More...