DegronMD

Uniprot ID: P01024

Source protein: Complement C3

Source gene: C3

Class: DEG_APCC_DBOX_1

Location: 925:933

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9457

ASA_SCORE: 62.9889

COIL: 0.3942

CONS_SCORE: 0.5515

DSS_SCORE: 0.2229

HELIX: 0.0469

FCONS_SCORE: 1.2533

RIG_SCORE: 0.8017

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G924C	TCGA-05-4396	LUAD	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.3056
p.G924C	DO23838	LUAD	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.3056
p.G924V	TCGA-17-Z022	LUAD	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.3056
p.V916I	TCGA-AX-A1CE	UCEC	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.0833
p.V916I	DO42280	UCEC	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.0833
p.S928A	TCGA-BH-A0DG	BRCA	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.7588
p.S928A	DO1257	BRCA	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.7588
p.E934K	TCGA-CN-A498	HNSC	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.3056
p.E934K	DO52038	HNSC	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.3056
p.V932M	TCGA-D1-A15X	UCEC	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.6097
p.V932M	DO43274	UCEC	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.6097
p.G935R	TCGA-EE-A29S	SKCM	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.2778
p.G935R	TCGA-EE-A2GR	SKCM	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.2778
p.G935R	DO37996	SKCM	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.2778
p.G935R	DO37936	SKCM	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.2778
p.L929M	TCGA-EE-A2M8	SKCM	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.711
p.L929M	DO38075	SKCM	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.711
p.K940T	TCGA-EO-A3B0	UCEC	TCGA	VRKSLKVVP	DEG_APCC_DBOX_1	0.25
p.K940T	DO219773	UCEC	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.25
p.A943T	DO231108	LAML	ICGC	VRKSLKVVP	DEG_APCC_DBOX_1	0.0556
p.F920L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VRKSLKVVP	DEG_APCC_DBOX_1	0.1944
p.F920L	ACH-000924	Lung Cancer	CCLE	VRKSLKVVP	DEG_APCC_DBOX_1	0.1944
p.F920L	NCI-H2172	lung	COSMIC	VRKSLKVVP	DEG_APCC_DBOX_1	0.1944
p.L929P	SIDM00680	Colorectal Carcinoma	GDSC	VRKSLKVVP	DEG_APCC_DBOX_1	0.7582
p.L929P	ACH-000957	Colon/Colorectal Cancer	CCLE	VRKSLKVVP	DEG_APCC_DBOX_1	0.7582
p.L929P	LS-180	large_intestine	COSMIC	VRKSLKVVP	DEG_APCC_DBOX_1	0.7582
p.S922G	SIDM01045	Endometrial Carcinoma	GDSC	VRKSLKVVP	DEG_APCC_DBOX_1	0.6944
p.S922G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VRKSLKVVP	DEG_APCC_DBOX_1	0.6944
p.S922G	EN	endometrium	COSMIC	VRKSLKVVP	DEG_APCC_DBOX_1	0.6944
p.P933L	SIDM01612	Endometrial Carcinoma	GDSC	VRKSLKVVP	DEG_APCC_DBOX_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRKSLKVVP

Degron related mutations and impact score

Drug responses associated with C3 mutations

All proteins holding degron of VRKSLKVVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01024	Complement C3	DEG_APCC_DBOX_1	925:933	VRKSLKVVP	APC,CDC20,FZR1	0.9457	More...