DegronMD

Uniprot ID: Q01826

Source protein: DNA-binding protein SATB1

Source gene: SATB1

Class: DEG_APCC_DBOX_1

Location: 189:197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7429

ASA_SCORE: 47.0778

COIL: 0.0244

CONS_SCORE: 0.6346

DSS_SCORE: 0.3769

HELIX: 0.9743

FCONS_SCORE: 1.0752

RIG_SCORE: 0.8141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D199H	TCGA-59-2349	OV	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	0.2778
p.D199H	DO28621	OV	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.2778
p.E182K	TCGA-BK-A6W3	UCEC	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	0.1389
p.E182K	DO50076	UCEC	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.1389
p.K194T	TCGA-BR-6452	STAD	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	0.6195
p.K194T	DO38404	STAD	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.6195
p.D195N	TCGA-FD-A6TG	BLCA	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	0.5821
p.D195N	DO49760	BLCA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.5821
p.P180L	TCGA-FW-A3R5	SKCM	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	0.0833
p.P180L	DO37406	SKCM	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.0833
p.Q183H	DO233712	GACA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.1667
p.D195E	DO228976	LICA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.5647
p.Q183K	DO229018	LICA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.1667
p.T187I	DO229462	SKCA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01826	DNA-binding protein SATB1	DEG_APCC_DBOX_1	189:197	VRNALKDLL	APC,CDC20,FZR1	0.7429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons