DegronMD - Q01826(SATB1)

FUNCTION: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis. Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone, possibly by positively regulating the expression of NEUROD1 (By similarity). {ECO:0000250|UniProtKB:Q60611, ECO:0000269|PubMed:10595394, ECO:0000269|PubMed:11463840, ECO:0000269|PubMed:12374985, ECO:0000269|PubMed:12692553, ECO:0000269|PubMed:1505028, ECO:0000269|PubMed:15618465, ECO:0000269|PubMed:15713622, ECO:0000269|PubMed:16377216, ECO:0000269|PubMed:16630892, ECO:0000269|PubMed:17173041, ECO:0000269|PubMed:17376900, ECO:0000269|PubMed:18337816, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:19247486, ECO:0000269|PubMed:19332023, ECO:0000269|PubMed:19430959, ECO:0000269|PubMed:33513338, ECO:0000269|PubMed:9111059, ECO:0000269|PubMed:9548713}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S295C	TCGA-22-0944	LUSC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295C	DO26766	LUSC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295C	DO27879	ORCA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295F	TCGA-22-5491	LUSC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295F	TCGA-D3-A8GI	SKCM	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295F	DO234161	ESAD	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295F	DO26420	LUSC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.S295F	DO50284	SKCM	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.D199H	TCGA-59-2349	OV	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.2778
p.D199H	DO28621	OV	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.2778
p.A286V	TCGA-AX-A2HC	UCEC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.0556
p.A286V	TCGA-BH-A18G	BRCA	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.0556
p.A286V	DO3686	BRCA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.0556
p.A286V	DO41572	UCEC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.0556
p.E182K	TCGA-BK-A6W3	UCEC	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.1389
p.E182K	DO50076	UCEC	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.1389
p.P305H	TCGA-BR-4362	STAD	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.P305H	DO38336	STAD	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.3056
p.K194T	TCGA-BR-6452	STAD	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation altering degron motif	0.6195
p.K194T	DO38404	STAD	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation altering degron motif	0.6195
p.H290Y	TCGA-D3-A8GL	SKCM	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1667
p.H290Y	DO50287	SKCM	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1667
p.H304Y	TCGA-EY-A215	UCEC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.6118
p.H304Y	DO42665	UCEC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.6118
p.D195N	TCGA-FD-A6TG	BLCA	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation altering degron motif	0.5821
p.D195N	DO49760	BLCA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation altering degron motif	0.5821
p.P180L	TCGA-FW-A3R5	SKCM	TCGA	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.0833
p.P180L	DO37406	SKCM	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.0833
p.R297Q	TCGA-LN-A49N	ESCA	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.7329
p.R297Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.7329
p.R297Q	ACH-000925	Lung Cancer	CCLE	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.7329
p.P311H	DO218693	GACA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.1389
p.Q183H	DO233712	GACA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.1667
p.T298K	DO228974	LICA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.7306
p.D195E	DO228976	LICA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation altering degron motif	0.5647
p.Q183K	DO229018	LICA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.1667
p.P299F	DO222411	MELA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation altering degron motif	0.6786
p.P294S	DO222572	MELA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.2778
p.T187I	DO229462	SKCA	ICGC	VRNALKDLL	DEG_APCC_DBOX_1	189:197	Mutation rewiring degron network	0.2778
p.S292G	SIDM00672	Hepatocellular Carcinoma	GDSC	VRTPLPNLH	DEG_APCC_DBOX_1	296:304	Mutation rewiring degron network	0.2222

Kaplan plot for SATB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SATB1

UniProt ID: Q01826

Entrez ID: 6304

Protein name: DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SATB1 in