DegronMD

Uniprot ID: Q01826

Source protein: DNA-binding protein SATB1

Source gene: SATB1

Class: DEG_APCC_DBOX_1

Location: 296:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.995

ASA_SCORE: 89.2444

COIL: 0.9361

CONS_SCORE: 0.5955

DSS_SCORE: 0.6299

HELIX: 0.024

FCONS_SCORE: 1.1158

RIG_SCORE: 0.6119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S295C	TCGA-22-0944	LUSC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295C	DO26766	LUSC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295C	DO27879	ORCA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295F	TCGA-22-5491	LUSC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295F	TCGA-D3-A8GI	SKCM	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295F	DO234161	ESAD	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295F	DO26420	LUSC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.S295F	DO50284	SKCM	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.A286V	TCGA-AX-A2HC	UCEC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.0556
p.A286V	TCGA-BH-A18G	BRCA	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.0556
p.A286V	DO3686	BRCA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.0556
p.A286V	DO41572	UCEC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.0556
p.P305H	TCGA-BR-4362	STAD	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.P305H	DO38336	STAD	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.3056
p.H290Y	TCGA-D3-A8GL	SKCM	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.1667
p.H290Y	DO50287	SKCM	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.1667
p.H304Y	TCGA-EY-A215	UCEC	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.6118
p.H304Y	DO42665	UCEC	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.6118
p.R297Q	TCGA-LN-A49N	ESCA	TCGA	VRTPLPNLH	DEG_APCC_DBOX_1	0.7329
p.R297Q	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VRTPLPNLH	DEG_APCC_DBOX_1	0.7329
p.R297Q	ACH-000925	Lung Cancer	CCLE	VRTPLPNLH	DEG_APCC_DBOX_1	0.7329
p.P311H	DO218693	GACA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.1389
p.T298K	DO228974	LICA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.7306
p.P299F	DO222411	MELA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.6786
p.P294S	DO222572	MELA	ICGC	VRTPLPNLH	DEG_APCC_DBOX_1	0.2778
p.S292G	SIDM00672	Hepatocellular Carcinoma	GDSC	VRTPLPNLH	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01826	DNA-binding protein SATB1	DEG_APCC_DBOX_1	296:304	VRTPLPNLH	APC,CDC20,FZR1	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTPLPNLH

Degron related mutations and impact score

Drug responses associated with SATB1 mutations

All proteins holding degron of VRTPLPNLH